Aseptic and Containment Isolator equipment has been built for the safe handling of hazardous substances, providing assured levels of worker safety. These include testing, dosing, blending, processing, etc. as well as overall process equipment such tablet press enclosures, filter dryer units, blenders, pack off systems, and grinders. These offer outstanding and dependable quality and construction, as well as a distinctive primary containment HEPA filtering system for optimal worker, product, and protection of the environment.
Aseptic Containment Using Negative Pressure Isolators are developed for the compounding of dangerous or powerful pharmaceutical chemicals, chemotherapeutic treatments, and IV combinations that can be detrimental to healthcare employees and demand both confinement and aseptic handling.
Negative Pressure Aseptic Containment Isolator offers a contained, negative pressure work zone to prevent migration of hazardous contaminants to the environment. HEPA-filtered entry / exit transfer chamber with prefilter provides a continuous inflow of sterile air. The air blends with the contaminated work area air and passes through a primary containment HEPA filter located below the work area. The filter arrests all particulates released within the work zone, thereby protecting fans, other internal components, maintenance technicians and the environment from contamination.
Applications of Containment Solutions
Aseptic Containment Using Negative Pressure (Recirculating) Isolators are useful laboratory tools for protecting all workers and the environment from any particulates, granules, or vapours that may be released during the production, modification, and dispensation of hazardous medications. Drugs must be manufactured or given in an atmosphere free of contaminants, including biological materials. And to protect support and inspection employees from drug residual that may infect cabinet filters, components, and other surfaces.
The Positive Pressure Aseptic Isolator with HEPA Filtration System delivers an enclosed, positive pressure worksite to maintain sterile environment for product safety. Cross-contamination inside the work zone is minimised by the airflow being HEPA-filtered in only single direction. Air-tight viewing windows establish a strong physical separation between the work area and the surroundings.
The pressure in the isolator working area is kept slightly higher than that in the transfer chamber so that it maintains a positive pressure to the space. Rubber gloves affixed to wide diameter glove openings are strategically positioned to allow better arm movement and perform operations in the isolator.
Aseptic Solutions Applications
Positive Pressure Compounding Aseptic Isolators are useful lab tools for acquiring the best possible influence on the product efficiency. They also satisfy the demands of pharmacy processes requiring the accumulation and delivering of non-hazardous prescription medicines or drugs, solutions and eyedrops, etc. as well as evaluate the appropriateness and pharmacy procedures that demand complete sterility.
Pharmaceutical items are frequently sterile tested before being released to the marketplace for delivery and usage using Positive Pressure Isolators with Primary Containment HEPA Filtration Systems.
Sterility Test Isolators
The final obligatory control done on sterile medications before their distribution to consumers is sterile testing. To prevent the chance of inaccurate results, it must be carried out in a systematic protected environment.
Types of Isolators –
- Sterility Test Isolators are developed to give workers to execute sterility testing in an antimicrobial atmosphere, ensuring the integrity of the procedure. They also allow for the regulated loading and unloading of treated product and waste materials from the Isolator enclosures.
- Reactor Sampling System is intended to provide safe, automated vacuum monitoring. Overspill and leakage of sample liquid, sample denial, reprocessing, and other quality-related difficulties, which eventually lead to human danger and reduced profits, are mitigated. These methods enable sampling at higher temperatures, of extremely corrosive solutions, and of the reactors without exposing the controller.
- Isolator Weighing systems are used in tandem with isolator systems to offer a safe working environment for toxic waste handling. Fluid/Solid weighing for medicines, bulk medications, chemicals, and foodstuff, weighing of unsafe, explosive, and poisonous compounds, and cGAMP powder manufacturing lines are all uses for these devices.
- Capsule Filling Isolators are commonly utilised in the pharmaceutical business. These highly competent barrier isolators are an essential component of the tablet blister production line, allowing the operator to correct any tablet process line packing abnormalities in a secure, sanitary, and totally enclosed environment.
- Vessel Charging Isolators are used by most pharmaceutical and chemical activities for charging or loading of reactors, dryers, filtration dryers, ANFs, storage vessels, and other containers with dangerous, powerful, and poisonous compounds. Furthermore, when performing such actions, vessel charging systems provide a cost-effective, secure worker environment for dangerous particles or liquids.
- Vacuum Tray Drying (VTD) Systems comes in both rigid and flexible barrier isolator layout variants When combined with barrier isolator system, these tray dryers offer a secure, sanitary, and economical small-scale tray drying solution. Vacuum Tray Drying (VTD) is a technique used in the preparation of sterile substances, the drying of extremely corrosive liquids, and the processing of pharmaceutical and chemical substances.
- Sterility Test Isolators are developed with ergonomics in mind to create a dependable appropriate atmosphere for sterility testing and other sterilising activities. Sterility Test Isolators are suited for conducting both simple inoculation and filter membrane sterility checks and may be decontaminated using various bio-decontamination methods.
- Bottle Filling Isolator solution offers dependable operation, simplicity of handling of individual components, secure interface function, more appropriate operational control of the bottle filling execution, easiness of the cumulative controls system, potential of longer, more efficacious bottle filling production numbers, advancement in bottle filling quality, and cost savings.
- Sampling, Dispensing & Sieving Isolators provide worker security from potentially dangerous and sensitising. The integrated solution also enhances the characteristics of the finished processed product by lowering the danger of possible contamination.
- Candle Filter Systems are capable of cake cleansing, thin-cake pressure filtering, re-slurring, drying, heel filtration, and automated discharge. They are commonly used for clarifying and recuperation tasks from fluids with low solids concentration. Candle filters are useful for treating solvents, strong acids, and other dangerous chemicals since the filtering is entirely confined.
- De-lumper Systems is a low-cost option for ensuring accurate particle size management. Prior encapsulating or tablet manufacture, processing facilities utilise De-Lumper to transform crystalised versions of chemicals to a dried free-flowing powder.
- Material Dispensing Systems are intended for pharmaceutical, chemical, and bulk-drug/API material processing, batching and production distribution operations, cGAMP processes, and other applications. These solutions decrease the possibility of exposure, provide excellent vision throughout functioning and cleaning, and are user friendly.
The Bottom Line
Isolators are made for evaluating the sterility of sterile products, parts, and equipment. Productivity is boosted by uninterrupted workflow, simple access, and quick bio-decontamination. Isolators shield the product from elements that can lower its quality and reduce the chance of receiving incorrect findings.