1) About Shree Bhagwati Machtech (India) Pvt. Ltd.?
Ans: Shree Bhagwati Machtech (India) Pvt. Ltd. is a leading manufacturer and supplier of Filling Machine, Capping & Labelling Machines in India.
Product manufacturing and processing is an intricate operation. It is commonly carried out with the appropriate machines and techniques. Manufacturing equipment should be available for each phase of the ongoing process. Shree Bhagwati Machtech (India) Pvt. Ltd. creates and sells a variety of machinery. After you’ve determined which method should be used on your raw goods, the following step is to place an order for the appropriate equipment.
2) Which Types of Machineries Offered by Shree Bhagwati Machtech?
Ans: Different Types of Machinery comes in a variety of shapes and sizes, each with its own function. Shree Bhagwati Machtech (India) Pvt. Ltd offers the following major types of filling, processing, labelling & packaging equipments:
- Washing Machinery
- Liquid Filling Machinery
- Powder Filling Machines
- Capping Machines
- Labelling Machinery
- Inspection Section
- Turn Table Section
- Blister Packaging Machinery
- Tablet Section
- Tablet Press Machines
- Other Products Section
Each piece of machinery on this list is clearly built for a certain purpose. Speak to us if you are unsure about the type of equipment you require. We will assist you in selecting the appropriate equipment as a reputable machine manufacturer.
3) Which Industries Need Processing Equipments?
Ans: Is it necessary for me to invest in processing equipments? You are welcome to inquire. If you make capsules, granules, or tablets, ointments, lotions, beverages, cosmetics, and more, you are the proper person to buy these processing equipments. The following are some of the industries that employ these machinery:
- Lube Packaging
- Cosmetics & Toiletries
- Edible Oil Industry
- Food And Ancillaries
- Pharmaceutical Industries
4) What to Keep in Mind While Buying Processing Machinery?
Ans: It is always prudent to ensure that you acquire the greatest quality, regardless of the sort of machinery you are about to purchase. When selecting Shree Bhagwati Machtech processing equipment, keep the following aspects in mind:
Ease of use: Based on your degree of experience, look for a machine that is simple to operate. It is essential to examine issues like the machine’s user interface.
Product requirements: Will the machine be able to meet the product’s physical requirements? Cooling and drying are just a few of the requirements.
Equipment quality: Examine the machinery extensively to confirm that it has been fine-tuned to perfection. Each component should be in flawless working order.
Maintenance: Is it affordable or costly to repair the machinery? When it comes to machine maintenance, cleaning is one of the concerns that can occur. To clean the equipment, what instruments will you need? Do you have to pay professionals or can you do it yourself?
Price of Equipment: What does a processing machine cost? Some are pricey, while others are inexpensive. Find out what the leading machine manufacturers & providers are charging.
The maximum capacity is: The functionality of the equipment and the rate at which it works with the raw ingredients determine its performance.
Some pieces of equipment have a large capacity, whereas others have a small one. Get one that best fits your manufacturing process.
5) What Influences The Wet Mixing Granulator’s Granulated Products?
Ans: Wet mixing granulators are a type of mixing and granulating machine that can be used to combine medicinal substances. In terms of technology, the wet mixing granulator integrates the two-step mixing and granulation processes, saving time while also meeting GMP requirements, reducing cross-contamination, and increasing efficiency. The approach has garnered positive feedback from users.
The conventional wet granulation procedure, on the other hand, has clear flaws when compared to the needs of modern formulation development. According to reports, powdered sugar, starch, dextrin, and other auxiliary materials are frequently employed in classic wet granulation. Powdered sugar, for example, is hygroscopic; starch will steadily hydrolyze and end up losing its swelling effect when exposed to acid, alkali, or under wet and heated situations; and dextrin interferes with the perseverance of the content of certain drugs, so conventional wet granulation has clear restrictions.
Traditional procedures also frequently employ subjective evaluations on the proportion of extracts and the uniformity of extracts to measure the amount of active ingredients, which has an impact on the preparations’ quality control requirements. If wet granulation technique is utilised to prepare granules for hygroscopic pharmaceuticals and excipients, the granules will be pushed together, generating stickiness, strip-like soft materials, adhesive nets, and other occurrences. The produced granules are overly hard, have little solubility, and are of inconsistent quality.
6) What Are Solid Dosage Forms’ Principles?
Ans: Pharmaceutical preparations in solid forms, often known as solid preparations, are referred to as solid dosage forms. Solid dosage forms, which account for nearly two-thirds of all clinical pharmaceutical preparations, are the most often utilised due to their superior stability and ease of storage. Powders, granules, capsules, pills, and other solid formulations are currently the most widely used clinically.
The wet granulator is among the most prominent solid dosage forms. It works by sucking the material into the container by vacuum suction (or manual feeding) and mixing it thoroughly using the vortex effect created by the agitator’s spinning. The granulating cutter will treat the churning material after putting the binder at the junction area. The dough is totally broken and sliced into uniform, thick spheres. It combines the processes of mixing and granulation. It can be used to mix and granulate powdery materials in the pharmaceutical, chemical, and light industry industries, as well as combining dry powder. This machine can suit the needs of the pharmaceutical sector for capsule and tablet granulation & mixing.
The two mixing and granulating operations are performed in the same container during the wet mixing granulation process. From the top of the conical hopper, the powdered material is poured into the material container. The powder material rotates in the container after the cover is closed due to the stirring impact of the stirring blade. Simultaneously, the material rolls along the tapering wall from the outside to the centre, generating a semi-flow. To ensure adequate mixing, the material is sheared and diffused. Due to the injection of the binder, the powder is steadily hydrated, and the material properties are altered, which solidifies the kneading, friction, & extrusion, of the material by the barrel wall & the blade, and form the structure a liquid bridge, and the material eventually turn into a loose soft powder. Forced extrusion is not used to granulate these soft materials with agglomerated structures; instead, a pelletizing knife is used to chop them. To achieve the phase change of the materials, the soft substances are chopped into small, homogeneous particles in a semi-fluid state. The discharge door is then opened, and the wet particles are pushed out of the hopper by the paddle’s centrifugal force.
7) What does it mean to have a continuous granulation line?
Ans: Granulation can be done before tableting to improve the flow and compaction properties of the powder. Continuous granulation with a twin screw extruder is an alternative to batch granulation for continuous tableting. “We continue to see demand in the pharmaceutical industry shift from batch to continuous production, as pharmaceutical production companies recognise the advantages, including lower costs and smaller batch sizes,” said Dirk Leister, Technical Marketing Manager for Process and Pharmaceutical Extruders at Thermo Fisher Scientific. The apparatus saves space and reduces material and API losses.”
Virtual real surveillance of the uninterrupted wet granulation process may improve not only the manufacturing of high-quality final goods, but also the knowledge of chemical and physical phenomena in the process, as well as lower the risk of defective products and wastage.
The market for continuous processing systems is in high demand given current regulatory attempts to increase productivity and reduce the risk of potential faults. Wet high-shear granulation, segmented dryer, and particle adjustment are the three modules that make up the system. The system injects dry crude ingredients separately or premixes the dry raw materials into the consistently high granulator in the granulation module. Following the completion of the small-scale dry mixing, the granulation liquid is poured to ensure that each granule absorbs the very same volume of liquid. The complete wet granulation procedure takes a few moments, yet just few gram of product are processed in that time, allowing for a speedier start-up without sacrificing quality. If the size of the particles needs to be adjusted varies the granulator’s working level; this will generate wet granules of consistent quality and density that will flow constantly into the drier. Wet grinding is not necessary because this procedure does not form large agglomerates.
The fluidized bed drying principle is used in the dryer module. It compresses the constantly flowing particles into 1.5 kg and then delivers them to a separate dryer chamber to dry. The dryer will transport the particles in this portion to the particle adjustment module after they achieve the correct moisture level, and then load anew bundle of wet particles for processing. Each pellet package’s drying curve is carefully checked. The system will assess the dried particles in the particle adjustment module to ensure that critical essential characteristics such as humidity, composition & particle sizes, uniformity are fulfilled. The machine can only process 6-9 kg of raw materials at a time, reducing the chance of output loss. Because of its modest size and modular design, the system is easy to deploy, expand, and connect with current equipment.
8) In the pharmaceutical industry, what are the uses of a fluidized bed dryer?
Ans: The drying process is a key part of the pharmaceutical manufacturing process. Although the drying equipment used in pharmaceutical preparations, variations, and process needs varies, one thing remains consistent: the employment of drying equipment to eliminate humidity (moisture or other liquids) from solid matter. Drying equipment comes in a variety of shapes and sizes. Fluidized bed drying is one of them, and it is a drying method that has advanced fast these days. Because of its applicability and superiority, the manufacturing method is frequently employed in the pharmaceutical business.
The implementation of fluidized techniques in the drying process is known as fluidized drying or boiling drying. When drying, the granular wet matter is first placed on the porous distribution plate, and hot air is drawn in through the lower portion of the plate. Between both the settling velocity of the solid particles and the speed of the airflow, the airflow rate is regulated. When the gas velocity is minimal, the particle layer is static and the bed height stays unchanged, resulting in a solid bed; as the gas velocity rises, the particle loosens and the bed layer rises somewhat; as the gas velocity rises, the particles migrate higher. The gas-solid combination generated in the bed is fluidized because it is floating and partly suspended in the air flow.
9) Fluidized bed dryer’s drying principle
Ans: Due to the countercurrent interaction of the gas-solid two phases and strong movement, the solid particles are suspended in the drying medium with a wide contact surface area. The mass transfer and heat transfer processes in fluidized bed drying technique are reciprocal. The hot air transports heat energy to the material’s surface by contact with the wet material during the convection drying process, and subsequently from the surface to the interior of the material. When a wet material is heated, the moisture content vaporises first, followed by the underlying moisture, which diffuses to the material’s surface in a liquid or gaseous condition and constantly vaporises into the air, reducing the moisture content of the material and completing the drying process. This is a method of mass transfer.
Wet granulation technology must keep up with the times as the pharmaceutical industry’s criteria for pharmaceutical procedures become more stringent. On the market, only more energy-saving, environmentally friendly, and safe granulation technologies are available. The researchers discovered that combining dynamic and static drying, a two-step drying approach utilised in the wet granulation drying process, can reduce the drying cycle of wet granules and boost production rates.